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Article

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

British journal of pharmacology - 1 Jun 2018

Moutal Aubin, Li Wennan, Wang Yue, Ju Weina, Luo Shizhen, Cai Song, François-Moutal Liberty, Perez-Miller Samantha, Hu Jackie, Dustrude Erik T, Vanderah Todd W, Gokhale Vijay, Khanna May, Khanna Rajesh

Abstract excerpt

BACKGROUND AND PURPOSE: N-type voltage-gated calcium (Cav 2.2) channels are critical determinants of increased neuronal excitability and neurotransmission accompanying persistent neuropathic pain. Although Cav 2.2 channel antagonists are recommended as first-line treatment for neuropathic pain, calcium-current blocking gabapentinoids inadequately alleviate chronic pain symptoms and often exhibit numerous side...

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PMID: 28161890
DOI: 10.1111/bph.13737
PMCID: PMC5980424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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