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Article

Molecular basis of toxicity of N-type calcium channel inhibitor MVIIA.

Neuropharmacology - 1 Feb 2016

Wang Fei, Yan Zhenzhen, Liu Zhuguo, Wang Sheng, Wu Qiaoling, Yu Shuo, Ding Jiuping, Dai Qiuyun

Abstract excerpt

MVIIA (ziconotide) is a specific inhibitor of N-type calcium channel, Cav2.2. It is derived from Cone snail and currently used for the treatment of severe chronic pains in patients unresponsive to opioid therapy. However, MVIIA produces severe side-effects, including dizziness, nystagmus, somnolence, abnormal gait, and ataxia, that limit its wider application. We previously identified a novel inhibitor of Cav2.2,...

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PMID: 26344359
DOI: 10.1016/j.neuropharm.2015.08.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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