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Article

Functional β1-selectivity of novel pyrazoloquinolinones at GABAA receptors revealed by electrophysiology, mutagenesis and docking.

European journal of pharmacology - 10 May 2026

Schnalzer Dominik, Haller Celina, Doppler Angelika M, Gashi Laureta, Asai Martyna, Bampali Konstantina, Koniuszewski Filip, Schaar Benjamin, Schnürch Michael, Mihovilovic Marko D, Khom Sophia, Ernst Margot

Abstract excerpt

Gamma-aminobutyric acid type A (GABAA) receptors are ligand-gated anion channels, encoded by nineteen subunit genes in mammals. Recent cryo-electron microscopy studies of native human receptors from brain cortex revealed that β1 subunits contribute to diverse assemblies, including non-canonical arrangements of subunits. β subunits contribute to both GABA binding sites and allosteric sites targeted by general...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42009093
DOI: 10.1016/j.ejphar.2026.178869

Genes

GABRB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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