Article

A rationally designed peptidomimetic modulator of CaV2.2 (N-type) voltage-gated calcium channels for chronic pain

2022-09-12

Abstract excerpt

<h4>Background: </h4> and Purpose Transmembrane Cav2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated pain targets. Clinical block of Cav2.2 (e.g., with Prialt) or indirect modulation (e.g., with gabapentinoids) mitigates chronic pain but is constrained by side effects. The cytosolic auxiliary subunit collapsin response mediator protein 2 (CRMP2) targets Cav2.2 to the senso...

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Literature Corpus work: f745b9fa-f758-5416-84e5-2e3a5081bb08
DOI: 10.22541/au.166299307.78275508/v1

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