Article

Structural insight into the mechanism of 4-aminoquinolines selectivity for the alpha2A-adrenoceptor

2019-02-27

Abstract excerpt

α 2A -adrenoceptor (AR) is a potential target for the treatment of degenerative diseases of the central nervous system, and α 2A -AR agonists are one of the most effective drugs for this condition. However, the lack of high selectivity for α 2A -AR subtype of traditional drugs greatly limits their clinic usage. In this study, a series of homobivalent 4-aminoquinolines conjugated by two 4-aminoquinoline moieties...

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Literature Corpus work: b6c2cd70-8b42-50bb-b672-ffa58d91c256
DOI: 10.1101/561894

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