Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypothetical membrane mechanisms in essential tremor.

Journal of translational medicine - 6 Nov 2008

Shaikh Aasef G, Miura Kenichiro, Optican Lance M, Ramat Stefano, Tripp Robert M, Zee David S

Abstract excerpt

BACKGROUND: Essential tremor (ET) is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Specifically, we propose that neural circuits controlling ballistic movements are inherently unstable due to their underlying reciprocal innervation. Such instability is enhanced by increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Computer Simulation
Share to Essential Tremor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Membrane Potentials

Share to Models, Neurological

Share to Motor Neurons

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 18990221
DOI: 10.1186/1479-5876-6-68
PMCID: PMC2613385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypothetical membrane mechanisms in essential tremor.PMID 18990221Read ↗

Biophysical modeling of VIM to assess contributions of oscillatory activity to essential tremorSemantic proximity Read ↗

Modeling mechanisms of tremor reduction for essential tremor using symmetric biphasic DBSSemantic proximity Read ↗

Evoked Resonant Neural Activity Long-Term Dynamics can be Reproduced by a Computational Model with Vesicle DepletionSemantic proximity Read ↗

The GABA Hypothesis in Essential Tremor: Lights and ShadowsSemantic proximity Read ↗

Circuitry dynamics of the cerebellum inform differential therapeutic responses and patient stratification in essential tremorSemantic proximity Read ↗

A multi-frequency whole-brain neural mass model with homeostatic feedback inhibitionSemantic proximity Read ↗

Autonomous oscillations and phase-locking in a biophysically detailed model of the STN-GPe networkSemantic proximity Read ↗

The GABA Hypothesis in Essential Tremor: Lights and ShadowsSemantic proximity Read ↗

Basal ganglia and cortical control of thalamic rebound spikesSemantic proximity Read ↗

A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron levelSemantic proximity Read ↗

Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational ModelSemantic proximity Read ↗

On the role of arkypallidal and prototypical neurons for phase transitions in the external pallidumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.