Article
The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion.
Nature communications - 26 Feb 2015
Gao Shangbang, Xie Lin, Kawano Taizo, Po Michelle D, Guan Sihui, Zhen Mei, Pirri Jennifer K, Alkema Mark J
Abstract excerpt
Persistent neural activity, a sustained circuit output that outlasts the stimuli, underlies short-term or working memory, as well as various mental representations. Molecular mechanisms that underlie persistent activity are not well understood. Combining in situ whole-cell patch clamping and quantitative locomotion analyses, we show here that the Caenorhabditis elegans neuromuscular system exhibits persistent...
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