Article

The mechanism underlying transient weakness in myotonia congenita

2020-12-24

Abstract excerpt

In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years of study. We made intracellular recordings from muscle of both genetic and pharmacologic mouse models of Becker disease to identify the mechanism underlying transient weakness. Our recordings reveal transient depola...

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Identifiers and source

Literature Corpus work: 62adbc20-04a9-5c07-9603-619f05ad8e37
DOI: 10.1101/2020.12.23.424129

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