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PINK1 is a target of T cell responses in Parkinson’s disease

17 Dec 2024

Abstract excerpt

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. While there is no curative treatment, the immune system's involvement with autoimmune T cells that recognize the protein α-synuclein (α-syn) in a subset of individuals suggests new areas for therapeutic strategies. As not all patients with PD have T cells specific for α-syn, we explored additional autoantigenic targets of T cells in...

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PMID: 39688918
DOI: 10.1172/jci180478

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