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Article

STK4 Deficiency Impairs Innate Immunity and Interferon Production Through Negative Regulation of TBK1-IRF3 Signaling.

Journal of clinical immunology - 1 Jan 2021

Jørgensen Sofie E, Al-Mousawi Ali, Assing Kristian, Hartling Ulla, Grosen Dorthe, Fisker Niels, Nielsen Christian, Jakobsen Marianne A, Mogensen Trine H

Abstract excerpt

BACKGROUND: STK4 deficiency due to homozygous mutations in the STK4 gene encoding the STK4/MST1 kinase was first described in 2012. STK4/MST1 kinase regulates cell proliferation, survival, differentiation, and immune responses through canonical and non-canonical Hippo signaling pathways. OBJECTIVE: We describe an 11-year-old girl with a clinical presentation consisting of severe recurrent herpes zoster, chronic...

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PMID: 33078349
DOI: 10.1007/s10875-020-00891-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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