Article
Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.
Cellular and molecular life sciences : CMLS - 1 May 2020
Buziau Amée M, Schalkwijk Casper G, Stehouwer Coen D A, Tolan Dean R, Brouwers Martijn C G J
Abstract excerpt
Hereditary fructose intolerance (HFI) is a rare inborn disease characterized by a deficiency in aldolase B, which catalyzes the cleavage of fructose 1,6-bisphosphate and fructose 1-phosphate (Fru 1P) to triose molecules. In patients with HFI, ingestion of fructose results in accumulation of Fru 1P and depletion of ATP, which are believed to cause symptoms, such as nausea, vomiting, hypoglycemia, and liver and...
Topics
- Animals
- Fructose
- Fructose Intolerance
- Genetic Predisposition to Disease
- Humans
- Mice
- Non-alcoholic Fatty Liver Disease