Article

Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate Isomerase

2025-04-09

Abstract excerpt

<title>Abstract</title> Fructose consumption increases risks of obesity-related metabolic diseases and some cancers, but remains controversial in hepatocellular carcinoma (HCC)1. Animal studies suggest high fructose promotes HCC2,3, whereas human studies found an inverse correlation between fructose intake and risk of live cancer4. Moreover, fructose metabolism is significantly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 39c18765-ec39-5d59-90af-9a474d5ada15
DOI: 10.21203/rs.3.rs-6049102/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dietary Fructose Suppresses Hepatocellular Carcinogenesis through Fructose 1-Phosphate-Mediated Inhibition of Mannose Phosphate IsomeraseDOI 10.21203/rs.3.rs-6049102/v1Read

Fructose-induced metabolic reprogramming of cancer cellsSemantic proximity Read

Targeting fructose metabolism for cancer therapySemantic proximity Read

Hepatic fructose metabolism is antagonized by growth hormone/insulin-like growth factor signaling via regulation of ketohexokinase expressionSemantic proximity Read

Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells.Semantic proximity Read

The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights.Semantic proximity Read

Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease.Semantic proximity Read

GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinaseSemantic proximity Read

Refined fructose and cancerSemantic proximity Read

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancerSemantic proximity Read

SIRT3-IDH2 axis is a target of dietary fructose: implication of IDH2 as a key player in dietary carcinogen toxicity in mice colonSemantic proximity Read

Metabolic stress-induced dysregulation of the Hippo signaling pathway inhibits the occurrence of hepatocarcinomaSemantic proximity Read

The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancerSemantic proximity Read