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Article

The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Aug 2015

Sweet Eric S, Saunier-Rebori Bernadette, Yue Zhenyu, Blitzer Robert D

Abstract excerpt

Parkinson's disease (PD) is a major movement disorder characterized by the loss of dopamine neurons and formation of Lewy bodies. Clinical and pathological evidence indicates that multiple brain regions are affected in PD in a spatiotemporal manner and are associated with a variety of motor and nonmotor symptoms, including disturbances in mood, executive function, and memory. The common PD-associated gene for...

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Source

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Identifiers

PMID: 26269629
DOI: 10.1523/JNEUROSCI.0040-15.2015
PMCID: PMC4532754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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