Article

Predicting the Pathogenicity of H3F3A and H3F3B Gene Variants in Cancer: An in Silico Study

2026-06-03

Abstract excerpt

<h4>Background: </h4> Histone H3.3 variants, encoded by the H3F3A and H3F3B genes, play a pivotal role in chromatin dynamics and gene regulation. Mutations in these genes have been implicated in various cancers, yet their precise pathogenicity remains unclear. This study employs an in silico approach to systematically evaluate the functional impact of single nucleotide variations (SNVs) in H3F3A and H3F3B and thei...

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Literature Corpus work: 232ebd36-a3e0-5791-8885-7cac9c2226d8
DOI: 10.20944/preprints202606.0207.v1

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