Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone variant H3F3A promotes lung cancer cell migration through intronic regulation.

Nature communications - 3 Oct 2016

Park Seong-Min, Choi Eun-Young, Bae Mingyun, Kim Sunshin, Park Jong Bae, Yoo Heon, Choi Jung Kyoon, Kim Youn-Jae, Lee Seung-Hoon, Kim In-Hoo

Abstract excerpt

Although several somatic single nucleotide variations in histone H3.3 have been investigated as cancer drivers, other types of aberration have not been well studied. Here, we demonstrate that overexpression of H3F3A, encoding H3.3, is associated with lung cancer progression and promotes lung cancer cell migration by activating metastasis-related genes. H3.3 globally activates gene expression through the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Histones

Share to Introns

Share to Neoplasm Metastasis

Share to Proportional Hazards Models

Share to Regulatory Elements, Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 27694942
DOI: 10.1038/ncomms12914
PMCID: PMC5477500

Genes

GPR87

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone variant H3F3A promotes lung cancer cell migration through intronic regulation.PMID 27694942Read ↗

Implications of canonical histone H3.1 and histone variant H3.3 in cancer.Semantic proximity Read ↗

Genes of the month: H3.3 histone genes: H3F3A and H3F3B.Semantic proximity Read ↗

Histone Variant H3.3: A versatile H3 variant in health and in disease.Semantic proximity Read ↗

Globular domain histone H3R131C mutation remodels chromatin accessibility to promote oncogenic transcriptional programsSemantic proximity Read ↗

Histone variants: emerging players in cancer biology.Semantic proximity Read ↗

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.Semantic proximity Read ↗

Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programsSemantic proximity Read ↗

Histone H3 G34 Tail Mutations in Cancer: Actions in Cis and Trans to Alter Chromatin and Gene Expression.Semantic proximity Read ↗

Predicting the Pathogenicity of H3F3A and H3F3B Gene Variants in Cancer: An in Silico StudySemantic proximity Read ↗

Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotypeSemantic proximity Read ↗

Non-neutral evolution of H3.3-encoding genes occurs without alterations in protein sequenceSemantic proximity Read ↗

The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.