Comprehensive Study of Human FBXW7 Deleterious nsSNP's Functional Inference and Susceptibility to Gynaecological Cancer

Abstract excerpt

<title>Abstract</title> <p>Cancer is one of the world's major causes of mortality, and it plays a most important role in the world's declining life expectancy. F-box and WD-40 domain protein 7 (FBXW7), a typical participant of the F-box family of proteins, has been considered as an antitumor protein and one of the maximum deregulated ubiquitin-proteasome system proteins in uterine carcinosarcoma, endometrial clea...

Topics

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• Amino Acid Substitution
• Enzyme Stability
• F-Box-WD Repeat-Containing Protein 7
• Mutation, Missense
• Neoplasm Proteins
• Protein Domains
• Signal Transduction
• Uterine Neoplasms

Identifiers and source

Literature Corpus work

603f3f7c-2d73-5a24-bce6-245361fb9d77

DOI

10.21203/rs.3.rs-692732/v1