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Article

Macrophage polarization toward M1 phenotype in T cell transfer colitis model.

BMC gastroenterology - 27 Nov 2023

Ebihara Shin, Urashima Toshiki, Amano Wataru, Yamamura Hideto, Konishi Noriko

Abstract excerpt

BACKGROUND: T cell transfer colitis model is often used to study the CD4+ T cell functions in the intestine. However, the specific roles of macrophages in colitis remain unclear. In this study, we aimed to evaluate the phenotype and functions of macrophages in the colonic lamina propria (LP) in a colitis model. METHODS: Colitis was induced in scid mice via the adaptive transfer of CD4+CD45RBhi T cells. Then, flow...

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Identifiers

PMID: 38012544
DOI: 10.1186/s12876-023-03054-1
PMCID: PMC10680295

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