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Article

Tumor-associated macrophage-specific LRRFIP1 promotes M2 macrophage polarization and progression of colorectal cancer via activation of the PI3K pathway.

Journal of translational medicine - 29 Jan 2026

Mu Silong, Zhang Shuomin, Wang Maihuan, Yuan Xinpu, Zou Guijun, Zhang Chaojun, Cao Zhen

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) liver metastasis is a major factor affecting the prognosis of advanced CRC. Tumor-associated macrophages (TAMs), play a crucial role in CRC progression and metastasis by influencing the EMT of tumor cells. LRR binding FLII interacting protein 1, an epigenetic regulatory gene, a cancer-associated gene in a comprehensive analysis of human genome sequences; however, its role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41612403
DOI: 10.1186/s12967-026-07759-1
PMCID: PMC12874990

Genes

LRRFIP1
FLII

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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