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Article

The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.

Experimental & molecular medicine - 1 May 2020

Lee Yeo Song, Song Su Jeong, Hong Hye Kyung, Oh Bo Young, Lee Woo Yong, Cho Yong Beom

Abstract excerpt

Colorectal cancer is a devastating disease with a low 5-year survival rate. Recently, many researchers have studied the mechanisms of tumor progression related to the tumor microenvironment. Here, we addressed the prognostic value of tumor-associated macrophages (TAMs) using a total of 232 CRC patient tissue samples and investigated the mechanisms underlying TAM-related colon cancer progression with respect to...

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Identifiers

PMID: 32444799
DOI: 10.1038/s12276-020-0436-7
PMCID: PMC7272616

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