Article

Integrated transcriptomic analysis reveals a metabolically quiescent state and gene expression networks related to intermediate and mature human 8-cell stage embryo resembling cells <i>in vitro</i>

2025-09-07

Abstract excerpt

<h4>Summary</h4> Human early development is challenging to study due to limited samples and cell numbers. The emergence of 8-cell stage embryo-like cells (8CLCs) offers new opportunities to understand embryonic genome activation (EGA) in humans. Our research compares and characterizes 8CLCs from various stem cell-based systems to determine how well these models reflect human early embryonic development. Using sin...

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Literature Corpus work: eada84a0-21d6-552e-9934-65d0aa00d5b2
DOI: 10.1101/2025.09.03.673953

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