Article

Peptide-HLA II interaction prediction for post-translationally modified peptides

2026-08-13

Abstract excerpt

CD4+ T cells recognize peptides presented by human leukocyte antigen (HLA) II, implementing a fundamental mediation mechanism of the adaptive immune system. Although post-translational modifications (PTMs) alter immune responses, PTM-peptide-HLA interaction prediction remains challenging due to data scarcity resulting from substoichiometric levels of PTMs. To overcome this, we developed PepChem, a deep learning mo...

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Literature Corpus work: 1f2f5eff-81ab-54e0-b780-57025caafd36
DOI: 10.64898/2026.08.07.743493

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