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Article

HLA-G and the MHC Cusp Theory.

Frontiers in immunology - 1 Jan 2022

Scavuzzi Bruna Miglioranza, van Drongelen Vincent, Holoshitz Joseph

Abstract excerpt

Human leukocyte antigens (HLA) are significant genetic risk factors in a long list of diseases. However, the mechanisms underlying these associations remain elusive in many cases. The best-characterized function of classical major histocompatibility complex (MHC) antigens is to allow safe presentation of antigenic peptides via a self/non-self-discrimination process. Therefore, most hypotheses to date have posited...

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Identifiers

PMID: 35281038
DOI: 10.3389/fimmu.2022.814967
PMCID: PMC8913506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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