Article
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.
The Journal of experimental medicine - 1 Jul 1993
Chicz R M, Urban R G, Gorga J C, Vignali D A, Lane W S, Strominger J L
Abstract excerpt
Naturally processed peptides were acid extracted from immunoaffinity-purified HLA-DR2, DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and Edman microsequencing, > 200 unique peptide masses were identified from each allele, ranging from 1,200 to 4,000 daltons (10-3...
Topics
- Alleles
- Amino Acid Sequence
- Chromatography, Affinity
- HLA-DR Antigens
- Molecular Sequence Data
- Molecular Weight
- Peptide Fragments