Article

Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

2021-05-04

Abstract excerpt

Human melanomas are commonly driven by activating mutations in BRAF , which promote melanocyte proliferation through constitutive stimulation of the MAPK pathway. However, oncogenic BRAF alone is insufficient to promote melanoma; instead, its expression merely induces a transient burst of proliferation that ultimately ceases with the development of benign nevi ( i . e . moles) comprised of growth-arrested mela...

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Literature Corpus work: 22795d47-05b3-5e8d-b210-76bc47a0c8f8
DOI: 10.1101/2021.05.04.442615

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