Article
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Cancer cell - 12 Jan 2015
Damsky William, Micevic Goran, Meeth Katrina, Muthusamy Viswanathan, Curley David P, Santhanakrishnan Manjula, Erdelyi Ildiko, Platt James T, Huang Laura, Theodosakis Nicholas, Zaidi M Raza, Tighe Scott, Davies Michael A, Dankort David, McMahon Martin, Merlino Glenn, Bardeesy Nabeel, Bosenberg Marcus
Abstract excerpt
Braf(V600E) induces benign, growth-arrested melanocytic nevus development, but also drives melanoma formation. Cdkn2a loss in Braf(V600E) melanocytes in mice results in rare progression to melanoma, but only after stable growth arrest as nevi. Immediate progression to melanoma is prevented by upregulation of miR-99/100, which downregulates mTOR and IGF1R signaling. mTORC1 activation through Stk11 (Lkb1) loss...
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