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Article

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.

Nature genetics - 1 May 2009

Dankort David, Curley David P, Cartlidge Robert A, Nelson Betsy, Karnezis Anthony N, Damsky William E, You Mingjian J, DePinho Ronald A, McMahon Martin, Bosenberg Marcus

Abstract excerpt

Mutational activation of BRAF is the earliest and most common genetic alteration in human melanoma. To build a model of human melanoma, we generated mice with conditional melanocyte-specific expression of BRaf(V600E). Upon induction of BRaf(V600E) expression, mice developed benign melanocytic hyperplasias that failed to progress to melanoma over 15-20 months. By contrast, expression of BRaf(V600E) combined with...

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Share to Mechanistic Target of Rapamycin Complex 1
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Neoplasm Metastasis

Share to Proteins

Share to Proto-Oncogene Proteins B-raf

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 19282848
DOI: 10.1038/ng.356
PMCID: PMC2705918

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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