Article
Inactivation of the Hippo tumor suppressor pathway promotes melanoma.
Nature communications - 29 Jun 2022
Vittoria Marc A, Kingston Nathan, Kotynkova Kristyna, Xia Eric, Hong Rui, Huang Lee, McDonald Shayna, Tilston-Lunel Andrew, Darp Revati, Campbell Joshua D, Lang Deborah, Xu Xiaowei, Ceol Craig J, Varelas Xaralabos, Ganem Neil J
Abstract excerpt
Melanoma is commonly driven by activating mutations in the MAP kinase BRAF; however, oncogenic BRAF alone is insufficient to promote melanomagenesis. Instead, its expression induces a transient proliferative burst that ultimately ceases with the development of benign nevi comprised of growth-arrested melanocytes. The tumor suppressive mechanisms that restrain nevus melanocyte proliferation remain poorly...
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