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Article

Melanocytic nevi and melanoma: unraveling a complex relationship.

Oncogene - 19 Oct 2017

Damsky W E, Bosenberg M

Abstract excerpt

Approximately 33% of melanomas are derived directly from benign, melanocytic nevi. Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAFV600E-activating mutations, will never progress to melanoma. Herein, we synthesize basic scientific insights and data from mouse models with common observations from clinical practice to comprehensively review melanocytic nevus biology. In...

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Share to Epigenomics
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nevus, Pigmented

Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 28604751
DOI: 10.1038/onc.2017.189
PMCID: PMC5930388

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