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Article

Decoding the Molecular Mechanisms of BRAF V600E-Induced Nevi Formation.

Biomedical and environmental sciences : BES - 20 Jul 2024

Liang Wei Zheng, Liu Yu Xuan, Xu Dan Dan, Jiang Wen Jie, Ran Ren Sen

Abstract excerpt

Melanocytes derived from neural crest cells harbor the BRAF V600E mutation, which is the predominant driver of nevus formation in humans. This mutation leads to malignant cell proliferation and subsequent cell cycle arrest, culminating in oncogene-induced senescence and nevus development. Nevertheless, emerging evidence has highlighted the heterogeneity of cellular senescence markers in BRAF V600E-induced...

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PMID: 39198241
DOI: 10.3967/bes2024.095

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