Article

Shift in pre-existing antibiotic heteroresistance explains AST change from susceptible to resistant during patient treatment

2025-11-28

Abstract excerpt

The development of resistance during antibiotic therapy can lead to treatment failure, negative outcomes, and even death. While bacterial development of resistance during therapy is observed relatively frequently, it is paradoxically thought to often be mediated by rare mutations (estimated frequency of ∼1 in 10^6 or less) and is generally viewed as an unpreventable event. Here, we describe the initial classificat...

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Literature Corpus work: 226b4cdf-9d2b-5c0a-a13b-96d1d676f114
DOI: 10.1101/2025.11.27.690971

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