Article

High-Resolution X-ray Structure of Gln143Asn Manganese Superoxide Dismutase Captures Multiple Hydrogen Peroxide Binding Sites

2025-07-19

Abstract excerpt

Human mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide (O ●− ) into hydrogen peroxide (H O ) and molecular oxygen (O ), serving as a key defense against oxidative damage. Despite extensive studies, the full structural characterization of H 2 O 2 -binding sites in MnSOD remains largely unexplored. Previous H 2 O 2 -soaked MnSOD structures have identified two distinct H 2 O 2 -binding...

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Literature Corpus work: 225f97bd-7a7d-5400-95c9-77a0184117a8
DOI: 10.1101/2025.07.17.665311

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