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Article

Engineering and characterization of human manganese superoxide dismutase mutants with high activity and low product inhibition.

The FEBS journal - 1 Nov 2006

Chockalingam Karuppiah, Luba James, Nick Harry S, Silverman David N, Zhao Huimin

Abstract excerpt

Human manganese superoxide dismutase is a mitochondrial metalloenzyme that is involved in protecting aerobic organisms against superoxide toxicity, and has been implicated in slowing tumor growth. Unfortunately, this enzyme exhibits strong product inhibition, which limits its potential biomedical applications. Previous efforts to alleviate human manganese superoxide dismutase product inhibition utilized rational...

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PMID: 16999822
DOI: 10.1111/j.1742-4658.2006.05484.x

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