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Article

Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase.

Biochemistry - 22 Apr 2008

Quint Patrick S, Domsic John F, Cabelli Diane E, McKenna Robert, Silverman David N

Abstract excerpt

The function in the structure, stability, and catalysis of the interfaces between subunits in manganese superoxide dismutase (MnSOD) is currently under scrutiny. Glu162 in homotetrameric human MnSOD spans a dimeric interface and forms a hydrogen bond with His163 of an adjacent subunit which is a direct ligand of the manganese. We have examined the properties of two site-specific mutants of human MnSOD in which...

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Identifiers

PMID: 18373354
DOI: 10.1021/bi7024518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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