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Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.

Biochemistry - 25 Dec 2007

Zheng Jiayin, Domsic John F, Cabelli Diane, McKenna Robert, Silverman David N

Abstract excerpt

Human manganese superoxide dismutase (MnSOD) is characterized by a product inhibition stronger than that observed in bacterial forms of MnSOD. Previous studies show that the conserved, active-site residue Tyr34 mediates product inhibition; however, the protein environment of Tyr34 is different in human and Escherichia coli MnSOD. We have prepared two site-specific mutants of human MnSOD with replacements of Phe66...

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PMID: 18044968
DOI: 10.1021/bi7014103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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