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Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites

2025-02-07

Abstract excerpt

<h4> Abstract </h4> Human NQO1 is a flavoenzyme essential for the redox metabolization of many substances and associated with wide-impacting diseases such as cancer and Alzheimeŕs. Recent X-ray crystallographic studies have proposed that a few residues at the active site of NQO1 (including Tyr126 and Tyr128) may control enzyme catalysis and functional negative cooperativity. In this work, we use rapid mixing pre...

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Literature Corpus work
c6b08640-ae97-5cff-9b21-edb15dffc42c
DOI
10.1101/2025.02.02.636097
Open publication

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Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sitesDOI 10.1101/2025.02.02.636097
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