Article

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

2025-02-21

Abstract excerpt

Superoxide dismutase 1 (SOD1) is a crucial enzyme that protects cells from oxidative damage by converting superoxide radicals into H 2 O 2 and O 2 . This detoxification process, essential for cellular homeostasis, relies on a precisely orchestrated catalytic mechanism involving the copper cation, while the zinc cation contributes to the structural integrity of the enzyme. This study presents the 2.3 Å crystal s...

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Literature Corpus work: 1b776745-f35a-52b5-a9ff-3e8fe2a556d1
DOI: 10.1101/2025.02.18.638811

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