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Exploring the molecular basis of human manganese superoxide dismutase inactivation mediated by tyrosine 34 nitration.

Archives of biochemistry and biophysics - 15 Mar 2011

Moreno Diego M, Martí Marcelo A, De Biase Pablo M, Estrin Darío A, Demicheli Verónica, Radi Rafael, Boechi Leonardo

Abstract excerpt

Manganese Superoxide Dismutase (MnSOD) is an essential mitochondrial antioxidant enzyme that protects organisms against oxidative damage, dismutating superoxide radical (O₂(.)⁻) into H₂O₂ and O₂. The active site of the protein presents a Mn ion in a distorted trigonal-bipyramidal environment, coordinated by H26, H74, H163, D159 and one ⁻OH ion or H₂O molecule. The catalytic cycle of the enzyme is a "ping-pong"...

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PMID: 21167124
DOI: 10.1016/j.abb.2010.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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