Article
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Biochemistry - 9 Apr 1996
Borgstahl G E, Parge H E, Hickey M J, Johnson M J, Boissinot M, Hallewell R A, Lepock J R, Cabelli D E, Tainer J A
Abstract excerpt
Human manganese superoxide dismutase (MnSOD) is a homotetrameric enzyme which protects mitochondria against oxygen-mediated free radical damage. Within each subunit, both the N-terminal helical hairpin and C-terminal alpha/beta domains contribute ligands to the catalytic manganese site. Two ident...
Topics
- Binding Sites
- Electrochemistry
- Enzyme Stability
- Genetic Variation
- Humans
- In Vitro Techniques
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Mutagenesis, Site-Directed
- Oxidative Stress
- Phenotype
- Point Mutation
- Polymorphism, Genetic