Article

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

2025-03-19

Abstract excerpt

Brain metastatic cells undergo metabolic adaptations, such as increased reliance on oxidative phosphorylation. Integrating proteomic and transcriptomic profiling of patient samples revealed a consistent upregulation of the carnosine dipeptidase-1 (CNDP1) in brain versus extracranial metastases. Carnosine is an abundant metabolite in brain and muscle, known to exert anti-proliferative effects on cancer cells. Here,...

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Literature Corpus work: 225e0f5d-a404-58c4-8468-a1d4b585e1f0
DOI: 10.1101/2025.03.18.644053

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