Article

Methylthioadenosine is Not Dramatically Elevated in <i>MTAP</i> -Homozygous Deleted Primary Glioblastomas

2019-09-16

Abstract excerpt

<h4>In Brief</h4> The co-deletion of MTAP in the CDKN2A locus is a frequent event in diverse cancers including glioblastoma. Recent publications report that significant accumulations of the MTAP substrate, methylthioadenosine (MTA), can sensitize MTAP -deleted cancer cells to novel inhibitors of PRMT5 and MAT2A for targeted therapy against tumors with this particular genetic alteration. In this work, using com...

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Literature Corpus work: 6f8943e1-f728-5e6f-91f7-ac63469248e2
DOI: 10.1101/769885

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