Article
Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
Pharmacological research - 1 Nov 2017
Oliveira Érica Aparecida de, Lima Diogenes Saulo de, Cardozo Lucas Esteves, Souza Garcia Ferreira de, de Souza Nayane, Alves-Fernandes Debora Kristina, Faião-Flores Fernanda, Quincoces José Agustín Pablo, Barros Silvia Berlanga de Moraes, Nakaya Helder I, Monteiro Gisele, Maria-Engler Silvya Stuchi
Abstract excerpt
Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance to anti-BRAF therapy usually develops within a few months and consequently there is a need to identify alternative therapies that will bypass BRAF inhibitor...
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