Article

Proteogenomic Characterization Reveals Therapeutic Opportunities Related to Mitochondrial Function in Melanoma

2022-10-25

Abstract excerpt

<h4>Summary</h4> The dynamics of more than 1900 mitochondrial proteins was explored through quantitative proteomics in 151 melanoma-related tissue samples of both surgical and autopsy origin. Dysregulation of mitochondrial pathways in primary tumors, metastases, and peritumoral tissues was correlated with age and survival of patients, as well as with tumor cell proliferation and the BRAF mutation status of the tu...

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Literature Corpus work: 5a5c73e8-6397-53ff-822b-b624e736d3d3
DOI: 10.1101/2022.10.24.513481

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