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Article

BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.

Oncogene - 1 Jan 2021

Han Anna, Purwin Timothy J, Bechtel Nelisa, Liao Connie, Chua Vivian, Seifert Erin, Sato Takami, Schug Zachary T, Speicher David W, Harbour J William, Aplin Andrew E

Abstract excerpt

Cancer cell metabolism is a targetable vulnerability; however, a precise understanding of metabolic heterogeneity is required. Inactivating mutations in BRCA1-associated protein 1 (BAP1) are associated with metastasis in uveal melanoma (UM), the deadliest adult eye cancer. BAP1 functions in UM remain unclear. UM patient sample analysis divided BAP1 mutant UM tumors into two subgroups based on oxidative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33208912
DOI: 10.1038/s41388-020-01554-y
PMCID: PMC7856044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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