Article

Oxidative Phosphorylation (OXPHOS) Promotes the Formation and Growth of Melanoma Lung and Brain Metastases

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Melanoma mortality is driven by the formation and growth of distant metastases. Here, we interrogated the role of tumor oxidative phosphorylation (OXPHOS) in the formation of distant metastases in melanoma. OXPHOS was the most upregulated metabolic pathway in primary tumors that formed distant metastases in the RCAS-TVA mouse model of spontaneous lung and brain metastases, and in melanoma patien...

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Literature Corpus work: c79c1061-b42a-5753-a019-0aa4d67729c5
DOI: 10.1101/2025.01.23.633049

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