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An <i>in vivo</i> screen identifies NAT10 as a master regulator of brain metastasis

2024-08-21

Abstract excerpt

Metastasis is the major cause of cancer-related deaths. Emerging evidence has shown that epigenetic regulation plays a fundamental role in cancer metastasis. To better understand the epigenetic regulation of metastasis, we conducted an in vivo shRNA screen for vulnerabilities of brain metastasis and identified N-acetyltransferase 10 (NAT10) as a driver of brain metastasis. Knockdown of NAT10 significantly restrain...

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Identifiers and source

Literature Corpus work
22e95417-8397-5fbb-b914-01113932941c
DOI
10.1101/2024.08.20.608711
Open publication

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An <i>in vivo</i> screen identifies NAT10 as a master regulator of brain metastasisDOI 10.1101/2024.08.20.608711
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