Article

Loss of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

2020-05-31

Abstract excerpt

<h4>Background</h4> Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of aspartate synthesis on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an important component of the malate-aspartate shuttle, impairs cytosolic aspartate levels, NAD + /NADH ratio, mitochondrial respira...

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Identifiers and source

Literature Corpus work: bc5114a0-6bb5-526a-b17a-a209bbf289fb
DOI: 10.1101/2020.05.29.121400

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