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Article

Emerging concepts and approaches for chemokine-receptor drug discovery

9 Oct 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: Chemokine receptors are most noted for their role in cell migration. However, inappropriate utilization or regulation of these receptors is implicated in many inflammatory diseases, cancer and HIV, making them important drug targets. AREAS COVERED IN THIS REVIEW: Allostery, oligomerization and ligand bias are presented as they pertain to chemokine receptors and their associated...

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Identifiers

PMID: 21132095
DOI: 10.1517/17460441.2010.525633

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