Article

A multiplexed, target-based phenotypic screening platform using CRISPR interference in <i>Mycobacterium abscessus</i>

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> The rise of difficult-to-treat Mycobacterium abscessus infections presents a growing clinical challenge due to the immense arsenal of intrinsic, inducible and acquired antibiotic resistance mechanisms that render many existing antibiotics ineffective against this pathogen. Moreover, the limited success in discovery of novel compounds that inhibit novel pathways underscores the need for innovati...

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Literature Corpus work: 437b527c-a6aa-551a-b70b-9e7346e68620
DOI: 10.1101/2025.03.17.643728

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