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Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD+/NADH dysregulation.

Future microbiology - 1 Apr 2020

Xu Junqi, Chen Yu, Mou Xi, Huang Yu, Ma Shuang, Zhang Liyuan, Zhang Yuan, Long Quanxin, Ali Md Kaisar, Xie Jianping

Abstract excerpt

Aim: To identify and characterize new mycobacterium pyrazinamide (PZA) resistance genes in addition to pncA, rpsA and panD. Materials & methods: To screen a Tn7 M. smegmatis mc2155 transposon library using 50 μM PZA and a PZA hypersensitive mutant (M492) was obtained. MIC was further used to confirm the hypersensitivity of M492 mutant by culturing the mutant in Middlebrook 7H9 liquid medium at 37°C....

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PMID: 32250176
DOI: 10.2217/fmb-2019-0071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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