Article

Sirt1 Mediates Neuroprotection from Mutant Huntingtin by Activation of TORC1 and CREB Transcriptional Pathway

2011-12-18

Abstract excerpt

Sirt1, an NAD-dependent protein deacetylase has emerged as important regulator of mammalian transcription in response to cellular metabolic status and stress(1). Here we demonstrate that Sirt1 plays a neuroprotective role in models of Huntington’s disease (HD), an inherited neurodegenerative disorder caused by a glutamine repeat expansion in huntingtin protein(2). Brain-specific knockout of Sirt1 results in exacer...

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Literature Corpus work: 224a0425-9f33-5fa9-92f5-f8a1930413c9
DOI: 10.1038/nm.2559

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